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Teresa Seeman

Teresa Seeman

Professor, Department of Geriatrics
University of California-Los Angeles
tseeman@mednet.ucla.edu
https://people.healthsciences.ucla.edu/institution/personnel?personnel_id=46887


Dr. Seeman's research interests focus on the role of socio-cultural factors in health and aging with specific interest in understanding the biological pathways through which these factors influence health and aging. A major focus of her research relates to understanding how aspects of the social environment, particularly social ties, influence health and aging. Dr. Seeman was a member of the MacArthur Research Network on Successful Aging (1985-1995) and directed data collection for the longitudinal MacArthur Study of Successful Aging. She has published extensively from this study and others on the role of social and psychological factors in aging. She is currently a member of the MacArthur Research Network on Socio-economic Status and Health. She has also served as a consultant to the Behavioral and Social Research Program at the National Institute on Aging on issues relating to the integration of physiological parameters into more socio-behavioral models of health and aging and currently serves as a member of the National Advisory Committee for the Robert Wood Johnson Health and Society Scholars Program. In collaboration with Drs. Bruce McEwen, and Burton Singer, she has taken a lead in empirical research on the new concept of allostatic load, with particular attention to both issues of measurement of the concept as well as empirical documentation of its relationship to both subsequent health outcomes as well as prior life circumstances.



Representative Publications
Sloan, R. P., Schwarz, E., McKinley, P. S., Weinstein, M., Love, G., Ryff, C., Mroczek, D., Choo, T. H., Lee, S., & Seeman, T. (2017). Vagally-mediated Heart rate variability and indices of well-being: Results of a nationally representative study. Health Psychology, 36(1), 73-81.
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Zahodne, L. B., Manly, J. J., Smith, J., Seeman, T., & Lachman, M. E. (2017). Socioeconomic, health, and psychosocial mediators of racial disparities in cognition in early, middle, and late adulthood. Psychology and Aging, 32(2), 118-130.
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Wiley, J. F., Gruenewald, T. L., Karlamangla, A. S., & Seeman, T. E. (2017). The authors reply: Pursuing the optimal operationalization of allostatic load. Psychosomatic Medicine, 79(1), 119-121 [Response to commentary on JF Wiley et al. (2016). Modeling multisystem physiological dysregulation.].
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Bei, B., Seeman, T. E., Carroll, J. E., & Wiley, J. F. (2017). Sleep and physiological dysregulation: A closer look at sleep intraindividual variability. Sleep. Advance online publication.
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Crowley, O. V., Kimhy, D., McKinley, P. S., Burg, M. M., Schwartz, J. E., Lachman, M. E., Tun, P. A., Ryff, C. D., Seeman, T. E., & Sloan, R. P. (2016). Vagal recovery from cognitive challenge moderates age-related deficits in executive functioning. Research on Aging, 38(4), 504-525.
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Galen Buckwalter, J., Castellani, B., McEwen, B., Karlamangla, A. S., Rizzo, A. A., John, B., O'Donnell, K., & Seeman, T. (2016). Allostatic load as a complex clinical construct: A case-based computational modeling approach. Complexity, 21(S1), 291-306.
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Wiley, J. F., Gruenewald, T. L., Karlamangla, A. S., & Seeman, T. E. (2016). Modeling multisystem physiological dysregulation. Psychosomatic Medicine, 78(3), 290-301.
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Hostinar, C. E., Davidson, R. J., Graham, E. K., Mroczek, D. K., Lachman, M. E., Seeman, T. E., van Reekum, C. M., & Miller, G. E. (2016). Frontal brain asymmetry, childhood maltreatment, and low-grade inflammation at midlife. Psychoneuroendocrinology, 75, 152-163.
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Kim, T. H., Carroll, J. E., An, S. K., Seeman, T. E., Namkoong, K., & Lee, E. (2016). Associations between actigraphy-assessed sleep, inflammatory markers, and insulin resistance in the Midlife Development in the United States (MIDUS) study. Sleep Medicine, 27-28, 72-79.
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Crandall, C. J., Karlamangla, A. S., Merkin, S. S., Binkley, N., Carr, D., Greendale, G. A., & Seeman, T. E. (2015). Adult bone strength of children from single-parent families: The Midlife in the U.S. Study. Osteoporosis International, 26(3), 931-942.
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Friedman, E. M., Karlamangla, A. S., Gruenewald, T., & Seeman, T. E. (2015). Early life adversity and adult biological risk profiles Psychosomatic Medicine, 77(2), 176-185.
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Cooper, T. M., McKinley, P. S., Seeman, T. E., Choo, T., Lee, S., & Sloan, R. P. (2015). Heart rate variability predicts levels of inflammatory markers: Evidence for the vagal anti-inflammatory pathway. Brain, Behavior, and Immunity, 49, 94-100.
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Carroll, J. E., Irwin, M. R., Merkin, S. S., & Seeman, T. E. (2015). Sleep and multisystem biological risk: A population-based study. PLoS ONE, 10(2), e0118467.
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Donoho, C. J., Seeman, T. E., Sloan, R. P., & Crimmins, E. M. (2015). Marital status, marital quality, and heart rate variability in the MIDUS cohort. Journal of Family Psychology, 29(2), 290-295.

Hostinar, C. E., Lachman, M. E., Mroczek, D. K., Seeman, T. E., & Miller, G. E. (2015). Additive contributions of childhood adversity and recent stressors to inflammation at midlife: Findings from the MIDUS study. Developmental Psychology, 51(11), 1630-1644.
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Friedman, E. M., Montez, J. K., Sheehan, C. M., Guenewald, T. L., & Seeman, T. E. (2015). Childhood adversities and adult cardiometabolic health: Does the quantity, timing, and type of adversity matter? Journal of Aging and Health, 27(8), 1311-1338.
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Brooks, K. P., Gruenewald, T. L., Karlamangla, A., Hu, P., Koretz, B., & Seeman, T. E. (2014). Social relationships and allostatic load in the MIDUS Study. Health Psychology, 33(11), 1373-1381.
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Karlamangla, A. S., Miller-Martinez, D., Lachman, M. E., Tun, P. A., Koretz, A., & Seeman, T. M. (2014). Biological correlates of adult cognition: Midlife in the United States (MIDUS). Neurobiology of Aging, 35(2), 387-394.
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Srikanthan, P., Crandall, C. J., Miller-Martinez, D., Seeman, T. E., Greendale, G. A., Binkley, N., & Karlamangla, A. S. (2014). Insulin resistance and bone strength. Findings from the study of Midlife in the United States. Journal of Bone and Mineral Research, 9(4), 796-803.
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Miller-Martinez, D., Seeman, T., Karlamangla, A. S., Greendale, G. A., Binkley, N., & Crandall, C. J. (2014). Marital histories, marital support, and bone density: Findings from the Midlife in the United States study. Osteoporosis International, 25(4), 1327-1335.
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Mori, T., Karlamangla, A. S., Merkin, S. S., Crandall, C. J., Binkley, N., Greendale, G. A., & Seeman, T. E. (2014). Multi-system dysregulation and bone strength: Finding from the Study of Midlife in the United States. Journal of Clinical Endocrinology and Metabolism, 99(5), 1843-1851.
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Seeman, M., Stein Merkin, S., Karlamangla, A., Koretz, B., & Seeman, T. (2014). Social status and biological dysregulation: The "status syndrome" and allostatic load. Social Science & Medicine, 118, 143-151.
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Hahn Rickenbach, E., Almeida, D. M., Seeman, T. E., & Lachman, M. E. (2014). Daily stress magnifies the association between cognitive decline and everyday memory problems: An integration of longitudinal and diary methods. Psychology and Aging, 29(4), 852-862.
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Karlamangla, A. S., Mori, T., Merkin, S. S., Seeman, T. E., Greendale, G. A., Binkley, N., & Crandall, C. J. (2013). Childhood socioeconomic status and adult femoral neck bone strength: Findings from the Midlife in the United States Study. Bone, 56(2), 320-326.
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Tun, P. A., Miller-Martinez, D., Lachman, M. E., & Seeman, T. (2013). Social strain and executive function across the lifespan: The dark (and light) sides of social engagement. Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition, 20(3), 320-338.
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Human, L. J., Biesanz, J. C., Miller, G. E., Chen, E., Lachman, M. E., & Seeman, T. E. (2013). Is change bad? Personality change is associated with poorer psychological health and greater metabolic syndrome in midlife. Journal of Personality, 81(3), 249-260.
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Donoho, C. J., Crimmins, E. M., & Seeman, T. E. (2013). Marital quality, gender, and markers of inflammation in the MIDUS cohort. Journal of Marriage and Family, 75(1), 127-141.
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Kimhy, D., Crowley, O. V., McKinley, P. S., Burg, M. M., Lachman, M. E., Tun, P. A., Ryff, C. D., Seeman, T. E., & Sloan, R. P. (2013). The association of cardiac vagal control and executive functioning- findings from the MIDUS study. Journal of Psychiatric Research, 47(5), 628-635.
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Swann, J. R., Spagou, K., Lewis, M., Nicholson, J. K., Glei, D. A., Seeman, T. E., Coe, C. L., Goldman, N., Ryff, C. D., Weinstein, M., & Holmes, E. (2013). Microbial-mammalian co-metabolites dominate the age-associated urinary metabolic phenotype in Taiwanese and American populations. Journal of Proteome Research, 12(7), 3166-3180.
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Karlamangla, A. S., Friedman, E. M., Seeman, T. E., Stawksi, R. S., & Almeida, D. M. (2013). Daytime trajectories of cortisol: Demographic and socioeconomic differences- findings from the National Study of Daily Experiences. Psychoneuroendocrinology, 38, 2585-2597.
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Crandall, C. J., Miller-Martinez, D., Greendale, G. A., Binkley, N., Seeman, T. E., & Karlamangla, A. S. (2012). Socioeconomic status, race, and bone turnover in the Midlife in the U.S. Study. Osteoporosis International, 23(5), 1503-1512.
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Gruenewald, T. L., Karlamangla, A. S., Hu, P., Stein-Merkin, S., Crandall, C., Koretz, B., & Seeman, T. E. (2012). History of socioeconomic disadvantage and allostatic load in later life. Social Science and Medicine, 74(1), 75-83.
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Friedman, E. M., Karlamangla, A. S., Almeida, D. M., & Seeman, T. E. (2012). Social strain and cortisol regulation in Midlife in the US. Social Science & Medicine, 74(4), 607-615.
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Chen, E., Miller, G. E., Lachman, M. E., Gruenewald, T. L., & Seeman, T. E. (2012). Protective factors for adults from low-childhood socioeconomic circumstances: The benefits of shift-and-persist for allostatic load. Psychosomatic Medicine, 74(2), 178-186.
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Gruenewald, T. L., Liao, D. H., & Seeman, T. E. (2012). Contributing to others, contributing to oneself: Perceptions of generativity and health in later life. The Journals of Gerontology Series B: Psychological Sciences and Social Sciences, 67(6), 660-665.
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Crandall, C. J., Merkin, S. S., Seeman, T. E., Greendale, G. A., Binkley, N., & Karlamangla, A. S. (2012). Socioeconomic status over the life-course and adult bone mineral density: The Midlife in the U.S. Study. Bone, 51(1), 107-113.
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Eaton, N. R., Krueger, R. F., South, S. C., Gruenewald, T. L., Seeman, T. E., & Roberts, B. W. (2012). Genes, environments, personality, and successful aging: Toward a comprehensive developmental model in later life. ournals of Gerontology. Series A, Biological sciences and medical sciences, 67(5), 480-488.
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Taylor, S. E., Karlamangla, A. S., Friedman, E. M., & Seeman, T. E. (2011). Early environment affects neuroendocrine regulation in adulthood. Social Cognitive and Affective Neuroscience, 6(2), 244-251.
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Seeman, T. E., Miller-Martinez, D. M., Stein Merkin, S., Lachman, M. E., Tun, P. A., & Karlamangla, A. S. (2011). Histories of social engagement and adult cognition: Midlife in the US study. Journals of Gerontology. Series B, Psychological Sciences and Social Sciences, 66B(Suppl 1), i141-i152.
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Crowley, O. V., McKinley, P. S., Burg, M. M., Schwartz, J. E., Ryff, C. D., Weinstein, M., Seeman, T. E., & Sloan, R. P. (2011). The interactive effect of change in perceived stress and trait anxiety on vagal recovery from cognitive challenge. International Journal of Psychophysiology, 82(3), 225-232.
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Miller, G. E., Lachman, M. E., Chen, E., Gruenewald, T. L., Karlamangla, A. S., & Seeman, T. E. (2011). Pathways to resilience: Maternal nurturance as a buffer against the Effects of childhood poverty on metabolic syndrome at Midlife. Psychological Science, 22(12), 1591-1599.
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Stawski, R. S., Almeida, D. M., Lachman, M. E., Tun, P. A., Rosnick, C. B., & Seeman, T. (2011). Associations between cognitive function and naturally occurring daily cortisol during middle adulthood: Timing is everything. The Journals of Gerontology Series B: Psychological Sciences and Social Sciences, 66B(suppl 1), i71-i81.
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Shcheslavskaya, O. V., Burg, M. M., McKinley, P. S., Schwartz, J. E., Gerin, W., Ryff, C. D., Weinstein, M., Seeman, T., Sloan, R. P. (2010). Heart rate recovery after cognitive challenge is preserved with age. Psychosomatic Medicine, 72(2), 128-133.
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Love, G. D., Seeman, T. E., Weinstein, M., & Ryff, C. D. (2010). Bioindicators in the MIDUS national study: Protocol, measures, sample and comparative context. Journal of Aging and Health, 22(8), 1059-1080.
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Greendale, G.A., Wight, R.G., Huang, M.H., Avis, N., Gold, E., Joffe, H., Seeman, T., Vuge, M., & Karlamangla, A.S. (2010). Menopause-associated symptoms and cognitive performance: Results from the Study of Women's Health Across the Nation. American Journal of Epidemiology, 171(11), 1214-1224.

Karlamangla, A.S., Merkin, S.S., Crimmins, E.M., & Seeman, T.E. (2010). Socioeconomic and ethnic disparities in cardiovascular risk in the United States, 2001-2006. Annals of Epidemiology, 20, 617-628.

Seeman, T.E., Merkin, S.S., Crimmins, E.M., & Karlamangla, A.S. (2010). Disability trends among older americans: National Health and Nutrition Examination Surveys, 1988-1994 and 1999-2004. American Journal of Public Health, 100(1), 100-107.

Seeman, T., Gruenewald,T., Karlamangla, A., Sidney, S., Liu, K., McEwen, B., & Schwartz, J. (2010). Modeling multisystem biological risk in young adults: The Coronary Artery Risk Development in Young Adults Study. American Journal of Human Biology, 22(4), 463-472.

Karlamangla, A.S., Miller-Martinez, D., Aneshensel, C.S., Wight, R.G., Seeman, T.E., & Chodosh, J. (2009). Trajectories of cognitive function in late life in the United States: Demographic and socioeconomic predictors. American Journal of Epidemiology, 170(3), 331-342.

Srikanthan, P., Seeman, T.E., & Karlamangla, A.S. (2009). Waist-hip ratio as a predictor of all-cause mortality in high-functioning older adults. Annals of Epidemiology, 19(10), 724-731.

Greendale, G.A., Huang, M.H., Wight, R.G., Seeman, T.E., Luetters, C., Avis, N.E., Johnston, J, & Karlamangla, A.S. (2009). Effects of the menopause transition and hormone use on cognitive performance in mid-life women: Results from the Study of Women's Health Across the Nation (SWAN). Neurology, 72, 1850-1857.

Merkin, S.S., Basurto-Davila, R., Karlamangla, A., Bird, C.E., Lurie, N., Escarce, J., & Seeman, T. (2009). Neighborhoods and cumulative biological risk profiles by race/ethnicity in a national sample of U.S. adults: NHANES III. Annals of Epidemiology, 19(3), 194-201.

Seeman, T., Merkin, S.S., Crimmins, E., Koretz, B., Charette, S., & Karlamangla, A. (2008). Education, income and ethnic differences in cumulative biological risk profiles in a national sample of US adults: NHANES III (1988-1994). Social Science and Medicine, 66(1), 72-87.

Sloan, R.P., Huang, M., McCreath, H., Sidney, S., Liu, K., Williams, O.D., & Seeman, T.S. (2008). Cardiac autonomic control and the effects of age, race, and sex: The CARDIA Study. Autonomic Neuroscience, 139, 78-85.

Chodosh, J., Kado, D., Seeman, T., & Karlamangla, A. (2007). Depressive symptoms as a predictor of cognitive decline: MacArthur Studies of Successful Aging. Journal of the American Geriatrics Society, 15(5), 406-15.

Hu, P., Wagle, N., Goldman, N., Weinstein, M., & Seeman, T. (2007). The associations between socioeconomic status, allostatic load, and measures of health in older Taiwanese persons: Taiwan Social Environment and Biomarkers of Aging Study. Journal of Biosocial Science, 39, 545-556.

Sloan, R.P., McCreath, H., Tracey, K. J., Sidney, S., Liu, K., & Seeman, T. (2007). RR interval variability is inversely related to inflammatory markers: The CARDIA study. Molecular Medicine, 13(3-4), 178-184.

Karlamangla, A.S., Singer, B., & Seeman, T.E. (2006). Reduction in allostatic load is associated with lower all-cause mortality risk in older adults. Psychosomatic Medicine, 68, 500-507.

Karlamangla, A.S., Singer, B., Williams, D., Schwartz, J., Matthews, K., Kiefe, C., & Seeman, TE. (2005). Impact of socioeconomic status on longitudinal accumulation of cardiovascular risk factors in young adults: The CARDIA Study. Social Science and Medicine, 60, 999-1015.

Seeman, T.E., Huang, M.H., Bretsky, P., Crimmins, E., Launer, L., & Guralnik, J.M. (2005). Education and APOE- ε4 in longitudinal cognitive decline: MacArthur Studies of Successful Aging. Journals of Gerontology. Series B, Psychological Sciences and Social Sciences, 60(2), P74-P83.

Karlamangla, A.S., Singer, B., Reuben, D., & Seeman, T. (2004). Increases in serum non-high-density-lipoprotein cholesterol over time may be beneficial in high-functioning elderly men and women: MacArthur Studies of Successful Aging. Journal of the American Geriatrics Society, 52(4), 487-494.

Karlamangla, A.S., Singer, B.H., McEwen, B.S., Rowe, J.W., Seeman, T.E. (2002). Allostatic load as a predictor of functional decline: MacArthur Studies of Successful Aging. Journal of Clinical Epidemiology, 55(7), 696-710.

Seeman, T. E., Singer, B. H., Ryff, C. D., Dienberg Love, G., & Levy-Storms, L. (2002). Social relationships, gender, and allostatic load across two age coherts. Psychosomatic Medicine, 64(3), 395-406.

Seeman, T.E., Singer, B., Ryff, C., & Levy-Storms, L. (2002). Social relationships, gender, and allostatic load across two age cohorts. Psychosomatic Medicine, 64, 395-406.

Seeman, T.E., McEwen, B.S., Rowe, J.W., & Singer, B.H. (2001). Allostatic load as a marker of cumulative biological risk: MacArthur Studies of Successful Aging. Proceedings of the National Academy of Sciences of the USA, 98(8), 4770-4775.

Seeman, T.E., Crimmins, E., Huang, M.H., Singer, B., Bucur, A., Gruenewald, T., Berkman, L.F., & Reuben, D.B. (1997). Cumulative biological risk and socio-economic differences in mortality: MacArthur Studies of Successful Aging. Social Science & Medicine, 58, 1985-1997.

Seeman, T.E., McEwen, B.S. (1996). Impact of social environment characteristics on neuroendocrine regulation. Psychosomatic Medicine, 58, 459-471.

Seeman, T.E., McAvay, G., Merrill, S., Albert, M., & Rodin, J. (1996). Self-efficacy beliefs and changes in cognitive performance: MacArthur Studies of Successful Aging. Psychology & Aging, 11, 538-551.

Seeman, T.E., Berkman, L.F., Gulanski, B.I., Robbins, R.J., Greenspan, S.L., Charpentier, P.A., & Rowe, J.W. (1995). Self-Esteem and neuroendocrine response to challenge: MacArthur Studies of Successful Aging. Journal of Psychosomatic Research, 39(1), 69-84.

Seeman, T.E., Berkman, L.F., Charpentier, P., Blazer, D., Albert, M., & Tinetti, M. (1995). Behavioral and psychosocial predictors of physical performance: MacArthur Studies of Successful Aging. Journals of Gerontology: Medical Science, 50A, M177-M183.

Seeman, T.E., & Robbins, R.J. (1994). Aging and hypothalamic-pituitary-adrenal response to challenge in humans. Endocrine Reviews, 15(2), 233-260.
©2011 University of Wisconsin - Madison, Institute on Aging