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Neil C. Binkley

Neil C. Binkley

Associate Director, Institute on Aging
University of Wisconsin- Madison
nbinkley@wisc.edu
http://www.aging.wisc.edu/research/affil.php?Ident=7


Bone loss with advancing age often leads to osteoporosis. As such, the lifetime risk of osteoporotic fracture is ~40% in women and 30% in men. Our research activities focus on the role of nutrition in bone loss, use of bone mass measurement in the diagnosis and treatment of osteoporosis, etiology of male osteoporosis and optimal treatment of people with osteoporosis.

It has become appreciated that vitamin D insufficiency is common and contributes to bone loss and perhaps other chronic diseases. Additionally, there is controversy regarding what constitutes low vitamin D, how to supplement and what target level should be achieved. We have completed work documenting that use of high-dose supplement regimens to replete vitamin D status is safe and effective in older adults. These data also demonstrate that there is a substantial between individual response to a given amount of vitamin D supplementation. We continue to build on our work evaluating vitamin D measurement methodology and have expanded into evaluating other non-skeletal effects of vitamin D insufficiency.

The evolution of fracture risk assessment tools and osteoporosis care are moving beyond bone to include comprehensive assessment of the musculoskeletal system. The impact of falls on fracture is well established, recently, the evaluation of sarcopenia, the age related decline in muscle mass, and it's impact on function, falls and fracture has been appreciated. Tools to assess lean muscle mass and diagnose sarcopenia are being evaluated for use in research and clinical settings. Our lab has done work using total body dual-energy x-ray absorptiometry to evaluate lean tissue and sarcopenia in older adults. We are also using jumping mechanography, a force platform that calculates maximum power, force and height from a series of jumps to evaluate function in older adults. These data demonstrate this is a safe and effective method to asses function and may be more sensitive to changes in muscle mass or activity than standard tools. Our long-term goals are to determine an effective way to identify sarcopenia, evaluate interventions and determine what impact this condition may have on fracture risk.

Our other interests include the clinical use of bone densitometry (bone density measurement), its interpretation and optimization of its diagnostic utility as well as bone mass measurement in males and non-Caucasians. Additionally, our group is active in clinical trials of future osteoporosis treatment medications and is conducting the first trial of an osteoporosis treatment medication in nursing home residents.



Representative Publications
Krueger, D., Siglinsky, E., Buehring, B., & Binkley, N. (2017). Total body less head measurement is most appropriate for lean mass assessment in adults. Clinical Densitometry, 20(1), 128-129.
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Yamada, Y., Buehring, B., Krueger, D., Anderson, R. M., Schoeller, D. A., & Binkley, N. (2016). Electrical properties assessed by bioelectrical impedance spectroscopy as biomarkers of age-related loss of skeletal muscle quantity and quality. Journals of Gerontology Series A: Biological Sciences and Medical Sciences. Advance online publication.
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Crandall, C. J., Karlamangla, A. S., Merkin, S. S., Binkley, N., Carr, D., Greendale, G. A., & Seeman, T. E. (2015). Adult bone strength of children from single-parent families: The Midlife in the U.S. Study. Osteoporosis International, 26(3), 931-942.
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Srikanthan, P., Crandall, C. J., Miller-Martinez, D., Seeman, T. E., Greendale, G. A., Binkley, N., & Karlamangla, A. S. (2014). Insulin resistance and bone strength. Findings from the study of Midlife in the United States. Journal of Bone and Mineral Research, 9(4), 796-803.
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Miller-Martinez, D., Seeman, T., Karlamangla, A. S., Greendale, G. A., Binkley, N., & Crandall, C. J. (2014). Marital histories, marital support, and bone density: Findings from the Midlife in the United States study. Osteoporosis International, 25(4), 1327-1335.
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Mori, T., Karlamangla, A. S., Merkin, S. S., Crandall, C. J., Binkley, N., Greendale, G. A., & Seeman, T. E. (2014). Multi-system dysregulation and bone strength: Finding from the Study of Midlife in the United States. Journal of Clinical Endocrinology and Metabolism, 99(5), 1843-1851.
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Karlamangla, A. S., Mori, T., Merkin, S. S., Seeman, T. E., Greendale, G. A., Binkley, N., & Crandall, C. J. (2013). Childhood socioeconomic status and adult femoral neck bone strength: Findings from the Midlife in the United States Study. Bone, 56(2), 320-326.
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Crandall, C. J., Miller-Martinez, D., Greendale, G. A., Binkley, N., Seeman, T. E., & Karlamangla, A. S. (2012). Socioeconomic status, race, and bone turnover in the Midlife in the U.S. Study. Osteoporosis International, 23(5), 1503-1512.
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Crandall, C. J., Merkin, S. S., Seeman, T. E., Greendale, G. A., Binkley, N., & Karlamangla, A. S. (2012). Socioeconomic status over the life-course and adult bone mineral density: The Midlife in the U.S. Study. Bone, 51(1), 107-113.
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Binkley, N., Gemar, D., Engelke, J., Gangnon, R., Ramamurthy, R., Krueger, D., & Drezner, M.K. (2011). Evaluation of ergocalciferol or cholecalciferol dosing, 1,600 IU daily or 50,000 IU monthly, in older adults. The Journal of Clinical Endocrinology & Metabolism. Advanced online publication..

Binkley, N., Ramamurthy, R., Krueger, D. (2010). Low vitamin D status: Definition, prevalence, consequences and correction. Endocrinology and Metabolism Clinics of North America, 39, 287-301.

Buehring, B., Krueger, D., Binkley, N. (2010). Jumping mechanography: A potential tool for sarcopenia evaluation in older individuals. Journal of Clinical Densitometry, 13, 283-291.

Binkley, N., Krueger, D., Morgan, S., Wiebe, D. (2010). Current status of clinical 25-hydroxyvitamin D measurement: An assessment of between-laboratory agreement. Clinica Chimica Acta, 411, 1976-1982.

Binkley, N., Harke, J., Krueger, D., Engelke, J., Vallarta-Ast, N., Gemar, D., Checovich,M., Chappell, R., & Suttie, J. (2009). Vitamin K treatment reduces undercarboxylated osteocalcin but does not alter bone turnover, density, or geometry in healthy postmenopausal North American women. Journal of Bone and Mineral Research, 24(6), 983-91.

Binkley, N., & Buehring, B. (2009). Beyond FRAX: it's time to consider "sarco-osteopenia". Journal of Clinical Densitometry, 12(4), 413-416.

Binkley, N., Krueger, D., & Lensmeyer, G. (2009). 25-hydroxyvitamin D measurement, 2009: a review for clinicians. Journal of Clinical Densitometry, 12(4), 417-427.

Przybelski, R., Agrawal, A., Krueger, D., Engelke, J.A., Walbrun, F., Binkley, N. (2008). Rapid correction of low vitamin D status in nursing home residents. Osteoporosis International, 19, 1621-1628.

Przybelski, N., Binkley, N. (2007). Is vitamin D important for preserving cognition? A positive correlation of serum 25-hydroxyvitamin D concentration with cognitive function. Archives of Biochemistry and Biophysics, 460, 202-205.

Binkley, N., Novotny, R., Krueger, D., Kawahara, T., Daida, Y.G., Lensmeyer, G., Hollis, B.W., & Drezner, M.K. (2007). Low vitamin D status despite abundant sun exposure. The Journal of Clinical Endocrinology and Metabolism, 92(6), 2130-5.

Binkley, N., Krueger, D., Engelke, J., Suttie, J.W. (2007). Vitamin K deficiency from long-term warfarin anticoagulation does not alter skeletal status in male rhesus monkeys. Journal of Bone and Mineral Research, 22, 695-700.

Binkley, N. (2007). Does low vitamin D status contribute to "age-related" morbidity? Journal of Bone and Mineral Research, 22(suppl 2), V55-V58.

Lensmeyer, G.L., Wiebe, D.A., Binkley, N., & Drezner, M.K. (2006). HPLC method for 25-hydroxyvitamin D measurement: comparison with contemporary assays. Clinical Chemistry, 52(6), 1120-6.

Vallarta-Ast, N., Krueger, D., Binkley, N. (2006). Addition of right lateral decubitus positioning improves vertebral visualization with VFA in selected patients. Journal of Clinical Densitometry, 6, 375-379.

Binkley, N., Drezner, M.K., & Hollis, B.W. (2006). Laboratory reporting of 25-hydroxyvitamin D results: Potential for clinical misinterpretation. Clinical Chemistry, 52(11), 2124-2125.
©2011 University of Wisconsin - Madison, Institute on Aging